Tablet Presentation

Each uncoated mouth dissolving tablet contains:
Cinnarizine IP 20 mg
Dimenhydrinate BP 40 mg

This composition is used together to vertigo. the drugs block the action of histamine which is responsible for vertigo. they work by preventing the constriction of blood vessels of the inner ear.

Indications

• Motion sickness
• Vertigo
• Nausea and vomiting
• Post-operative nausea and vomiting

About Composition

Cinnarizine-

Cinnarizine belongs to the class of calcium channel blocker. It mainly inhibits the signal transduction and between the vomiting centre of the hypothalamus and vestibular apparatus of the inner ear.

Dimenhydrinate-

It is over the counter drug and is used in the treatment of nausea, vomiting and motion sickness. It directly inhibits the stimulation of certain nerves in the brain.

Mechanism of Action

Cinnarizine reduces contraction of smooth muscles by blocking the L-Type and T-type voltage gated calcium channels.
Dimenhydrinate blocks the H1 receptor in vestibular center in the brain.

Side Effects

• Drowsiness
• Sweating
• Dry mouth
• Headache
• Skin problems
• Lethargic

Contraindications

Contraindicated in people with known hypersensitivity

Drug Interactions

• Warfarin
• Methadone
• Paracetamol
• Scopolamine
• Meclizine

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